Binding of Human Urokinase Type Plasminogen Activator and Plasminogen to Borrelia Species
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چکیده
منابع مشابه
Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.
An approximately 75% pure form of a human Mr approximately 54,000 plasminogen activator inhibitor from conditioned culture fluid of the fibrosarcoma cell line HT-1080 was obtained by a single step of chromatography on concanavalin A-Sepharose. The inhibitor inhibited human urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator, but not plasmin. Rabbit antibodies again...
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Urokinase-type plasminogen activator (UPA), particularly when bound to its receptor (UPAR), is thought to play a major role in local proteolytic processes, thus facilitating cell migration as may occur during angiogenesis, neointima and atherosclerotic plaque formation, and tumor cell invasion. To facilitate understanding of the need and function of the UPA/UPAR interaction in cell migration an...
متن کاملExpression of urokinase-type plasminogen activator in human preimplantation embryos.
During embryo implantation in the human trophoblast cells invade the endometrium and plasminogen activators (PA) are implicated in this tissue invasion process. Our studies on surplus embryos from patients undergoing in-vitro fertilization (IVF) treatments showed that PA activity was present in secretions of blastocysts but not embryos at the 2-4-cell stage. The secretion of this PA activity by...
متن کاملUrokinase-type plasminogen activator in human aqueous humor.
In the anterior segment of the eye, fibrin clots must be rapidly resorbed to prevent further fibrosis and scarring. The aqueous humor of patients undergoing cataract surgery was analyzed for the presence of components of the fibrinolytic cascade. In 30 patients, aqueous humor and plasma were compared for their content of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activa...
متن کاملHuman Brain Tumors and Plasminogen Activator Inhibitor Type-1 in Malignant Elevated Levels of Urokinase-Type Plasminogen Activator
The plasminogen-plasmin system has been found to modulate neoplastic spread and angiogenesis in tumors outside the central nervous system (CNS), but there have been no quantitative studies on the invasive and vascular tumors of the CNS. Quantitative zymography and enzyme-linked immunosorbent assay were used to determine the amounts of urokinasetype plasminogen activator (u-PA), tissue-type plas...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 1996
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/174.1.97